SARS-CoV-2 genomics update

Trevor Bedford (@trvrb)
Fred Hutchinson Cancer Center / Howard Hughes Medical Institute
19 Jul 2022
Viruses and Vaccines Seminar Series
Brotman Baty Institute
 
Slides at: bedford.io/talks

Global SARS-CoV-2 evolution over the course of the pandemic

BA.5 is now dominant in the US (and most of the world)

Variant-specific epidemics shown by partitioning case counts by variant frequency

Variant-specific Rt decreasing as immunity accumulates

BA.2.75 emerging from India that possesses a number of spike mutations on top of BA.2

Frequency growth outpacing BA.5 in India

Inferred initial Rt>2, but rapidly decreasing due to lack of growing case counts in India

Acknowledgements

SARS-CoV-2 genomic epi: Data producers from all over the world, GISAID and the Nextstrain team

Bedford Lab: John Huddleston,   James Hadfield,   Katie Kistler,   Louise Moncla,   Maya Lewinsohn,   Thomas Sibley,   Jover Lee,   Cassia Wagner,   Miguel Paredes,   Nicola Müller,   Marlin Figgins,   Denisse Sequeira,   Victor Lin,   Jennifer Chang