SARS-CoV-2 genomics update


Trevor Bedford (@trvrb)
Fred Hutchinson Cancer Center / Howard Hughes Medical Institute
16 May 2023
Viruses and Vaccines Seminar Series
Brotman Baty Institute
Slides at:

Population immunity has driven a dramatic shift in death toll

But this immunity is now driving evolution of the virus

In which new variants emerge that escape from existing population immunity and spread rapidly

Mutations at spike S1 propel escape from population immunity

These mutations are continuing just as quickly post-Omicron

And are accruing much more rapidly than other endemic viruses

In this light, mutations at 478 and 486 are the latest salvo in an ongoing war, with XBB.1.16 currently the most successful lineage

XBB.1.16 is now rapidly displacing circulating viruses

XBB.1.16 shows a 20-30% growth advantage over even XBB.1.5


SARS-CoV-2 genomic epi: Data producers from all over the world, GISAID and the Nextstrain team

Bedford Lab: John Huddleston, James Hadfield, Katie Kistler, Thomas Sibley, Jover Lee, Cassia Wagner, Miguel Paredes, Nicola Müller, Marlin Figgins, Victor Lin, Jennifer Chang, Allison Li, Eslam Abousamra, Donna Modrell, Cécile Tran Kiem