SARS-CoV-2 genomics update


Trevor Bedford (@trvrb)
Fred Hutchinson Cancer Center / Howard Hughes Medical Institute
20 Sep 2022
Viruses and Vaccines Seminar Series
Brotman Baty Institute
Slides at:

Rapid displacement of existing diversity by emerging variants

S1 evolved at a rate of 13 amino acid changes per year since pandemic start

Continued rapid accumulation from BA.2 onwards with 7 amino acid changes per year

BA.2.75 and sublineage BA.2.75.2 emerging from India

BA.2.75(.2) shows consistent selective advantage in India and US

BA.2.75.2 has current Rt in the US of ~1.4

However, multiple low frequency Pango lineages that may compete with BA.2.75.2


SARS-CoV-2 genomic epi: Data producers from all over the world, GISAID and the Nextstrain team

Bedford Lab: John Huddleston, James Hadfield, Katie Kistler, Maya Lewinsohn, Thomas Sibley, Jover Lee, Cassia Wagner, Miguel Paredes, Nicola Müller, Marlin Figgins, Denisse Sequeira, Victor Lin, Jennifer Chang, Jennifer Chang, Donna Modrell