Seasonal Flu Update From The Experts


Michael Boeckh, Helen Chu, Jesse Bloom, Trevor Bedford
5 Nov 2019
VIDD Seminar
Fred Hutch

Vaccine strain selection for seasonal influenza viruses

Trevor Bedford (@trvrb)

Vaccine strain selection by WHO

One strain chosen per seasonal lineage

Most rapid evolution in H3N2

Recent diversification of H3N2

Recent H3N2 vaccine choices

North American viruses from summer and early fall are predominantly A1b

Sera raised against Kansas/17 targets 3c3.A, but not A1b viruses

Sera raised against South Australia/34 targets A1b, but not 3c3.A viruses

Larger issue with egg-adaptation in recent H3N2 viruses

Immediate improvements to seasonal influenza vaccine platform

  1. Move to cell-based, pure protein or RNA vaccine
  2. Incorporate neuraminidase
  3. Pick vaccine sequence in ~Jun for ~Oct distribution


Bedford Lab: Alli Black, John Huddleston, James Hadfield, Katie Kistler, Louise Moncla, Maya Lewinsohn, Thomas Sibley, Jover Lee, Kairsten Fay, Misja Ilcisin, Nicola Müller

Seasonal flu: WHO Global Influenza Surveillance Network, GISAID, Richard Neher, John Huddleston, Jover Lee, Barney Potter, Dave Wentworth, Becky Garten   Nextstrain: Richard Neher, James Hadfield, Emma Hodcroft, Tom Sibley, John Huddleston, Sidney Bell, Barney Potter, Colin Megill, Charlton Callender, Jover Lee, Misja Ilcisin, Kairsten Fay