Seasonal Flu Update From The Experts
Michael Boeckh, Helen Chu, Jesse Bloom, Trevor Bedford
5 Nov 2019
VIDD Seminar
Fred Hutch
Vaccine strain selection for seasonal influenza viruses
Trevor Bedford (@trvrb)
Vaccine strain selection by WHO
One strain chosen per seasonal lineage
Most rapid evolution in H3N2
Recent diversification of H3N2
Recent H3N2 vaccine choices
North American viruses from summer and early fall are predominantly A1b
Sera raised against Kansas/17 targets 3c3.A, but not A1b viruses
Sera raised against South Australia/34 targets A1b, but not 3c3.A viruses
Larger issue with egg-adaptation in recent H3N2 viruses
Immediate improvements to seasonal influenza vaccine platform
- Move to cell-based, pure protein or RNA vaccine
- Incorporate neuraminidase
- Pick vaccine sequence in ~Jun for ~Oct distribution
Acknowledgements
Bedford Lab:
Alli Black,
John Huddleston,
James Hadfield,
Katie Kistler,
Louise Moncla,
Maya Lewinsohn,
Thomas Sibley,
Jover Lee,
Kairsten Fay,
Misja Ilcisin,
Nicola Müller
Seasonal flu: WHO Global Influenza Surveillance Network, GISAID, Richard Neher, John Huddleston, Jover Lee, Barney Potter, Dave Wentworth, Becky Garten Nextstrain: Richard Neher, James Hadfield, Emma Hodcroft, Tom Sibley, John Huddleston, Sidney Bell, Barney Potter, Colin Megill, Charlton Callender, Jover Lee, Misja Ilcisin, Kairsten Fay
