Why do some people develop more bnAbs?
Can we induce high levels in everyone?
How can we guarantee they will dominate?
A story about a sample of people born between 1965 and 1979...
Order (Age?) of infection
H3N2: 33% (95% CI: 26-39)
B: 54% (46-61)
pH1N1: 61% (57-65)
H1N1: 67% (29-85)
Poor strain selection (antigenic mismatch)
Egg adaptations (antigenic mismatch)
Interaction with pre-existing immune responses
Ferrets recognize egg adaptations, but humans don't