SARS-CoV-2 genomics update
Trevor Bedford (@trvrb)
Fred Hutchinson Cancer Center / Howard Hughes Medical Institute
20 Sep 2022
Viruses and Vaccines Seminar Series
Brotman Baty Institute
Slides at: bedford.io/talks
Rapid displacement of existing diversity by emerging variants
S1 evolved at a rate of 13 amino acid changes per year since pandemic start
Continued rapid accumulation from BA.2 onwards with 7 amino acid changes per year
BA.2.75 and sublineage BA.2.75.2 emerging from India
BA.2.75(.2) shows consistent selective advantage in India and US
BA.2.75.2 has current Rt in the US of ~1.4
Model from Figgins and Bedford. 2022. medRxiv.
However, multiple low frequency Pango lineages that may compete with BA.2.75.2
Acknowledgements
SARS-CoV-2 genomic epi: Data producers from all over the world, GISAID and the Nextstrain team
Bedford Lab:
John Huddleston,
James Hadfield,
Katie Kistler,
Maya Lewinsohn,
Thomas Sibley,
Jover Lee,
Cassia Wagner,
Miguel Paredes,
Nicola Müller,
Marlin Figgins,
Denisse Sequeira,
Victor Lin,
Jennifer Chang,
Jennifer Chang,
Donna Modrell
