Evolutionary analysis of USVI Zika epidemic

Genetic characterization of the Zika virus epidemic in the US Virgin Islands

Allison Black1,2, Barney Potter1, Gytis Dudas1, Leora Feldstein1, Nathan D. Grubaugh3, Kristian G. Andersen3, Brett R. Ellis4, Esther M. Ellis4, Trevor Bedford1

1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, 2Department of Epidemiology, University of Washington, Seattle, WA, USA, 3Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA, 4United States Virgin Islands Department of Health, Christiansted, USVI

Abstract

Here we release draft genome sequences of Zika virus (ZIKV) that were sequenced from PCR-positive diagnostic specimens collected by the United States Virgin Islands Department of Health (USVI DoH) as part of their ongoing response to the ZIKV outbreak. We will use these sequences to conduct a genomic epidemiological study of ZIKV transmission in the USVI. We are releasing these genomes in the hope that they are useful for those individuals involved in the public health response to ZIKV and to other groups working to understand Zika virus transmission and evolution.

Purpose

This work represents a pre-publication sharing of pathogen genomic data of public health significance. We believe that open sharing of sequence data and early analyses is necessary to inform public health response in a timely fashion. We encourage other investigators to use these data in their own analyses to better contextualize their work. All we ask is that you let us know if you plan to use these data in a publication. We intend for this announcement to serve as a 'marker paper' specifying analyses we have planned for these data, namely to investigate Zika transmission in the USVI. For greater detail please see the 'Genome Announcement'. We plan to replace this 'announcement' with a preprint and eventually with a publication. The citation will be continually updated throughout this process.

Black A, Potter B, Dudas G, Feldstein L, Grubaugh ND, Andersen KG, Ellis BR, Ellis EM, Bedford T. 2017. Genetic characterization of the Zika virus epidemic in the US Virgin Islands. DOI: 10.1101/113100.

Outline